SPRAVATO in Pittsburgh

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Depression can feel like a constant weight that affects every aspect of your life. Finding a treatment that works can be difficult and overwhelming, as traditional therapies often take a while to work, may come with unpleasant side effects, or may not provide relief.

If you have been living with this mental health condition and have not found relief through antidepressants, SPRAVATO in Pittsburgh may restore your hope and improve your mood. Administered in our office under the supervision of our experienced and compassionate clinicians, this advanced depression treatment offers a safe and fast-acting solution for people experiencing depressive symptoms.

What Is SPRAVATO?

SPRAVATO is an FDA-Aproved esketamine-based nasal spray that can help treat major depressive disorder (MDD) in adults with treatment-resistant depression—defined as depression with symptoms that have not improved through treatment with two or more different oral antidepressants—as well as those experiencing suicidal ideation (SI). It is an innovative and fast-acting way to treat depression and restore long-awaited wellness for those seeking an alternative option.

Esketamine nasal spray works differently from traditional antidepressants you may have tried in Pittsburgh. This treatment works by increasing glutamate receptors in the brain and boosting neuroplasticity, which is the brain’s ability to form and repair important connections involved in mood and cognition that may have weakened due to prolonged depression.

Does SPRAVATO Work?

MDD is one of the most common mental health disorders in the country. Symptoms include depressed mood, loss of interest in daily activities, and changes in sleep, appetite, or weight. While oral medications can be effective in treating MDD, one in three people do not see an improvement in symptoms from taking pills.

In contrast, a recent study showed that 88 percent of patients experienced significant improvement within three months of SPRAVATO use. Many people experience relief much sooner, sometimes even within a day. While SPRAVATO may be the only FDA-cleared esketamine-based nasal spray currently available in Pittsburgh, research shows it is highly effective when taken according to recommended treatment schedules. For those who can tolerate antidepressants, it can be even more effective when used in combination with them.

Are You a Good Candidate?

SPRAVATO is generally safe and well-tolerated by most people. You may be a good candidate if you have treatment-resistant depression or SI.

Like any medication, SPRAVATO comes with side effects and risks. It can temporarily raise your blood pressure, so it may not be a good option for you if you have uncontrolled medical conditions such as hypertension, heart disease, or aneurysms. Additionally, if you have a history of substance use disorders, SPRAVATO may not be the most appropriate treatment for you.

The best way to determine whether you are a good candidate for this innovative esketamine treatment is by scheduling an initial appointment with our team in Pittsburgh. During this visit, one of our board-certified clinicians will review your health history, current symptoms, and treatment goals. Be sure to inform us of any medical conditions, surgeries, and current or past medications so we can ensure your safety during treatment. Once we determine your eligibility, we will be able to create a customized treatment plan that addresses your unique needs.

Spravato Treatment

What to Expect During Treatment

    • Your Spravato treatment will begin with a detailed consultation and assessment by our team.
    • Once approved for Spravato, you will visit the office twice a week during the initial phase of treatment.
    • At each session, you will self-administer the nasal spray in a comfortable clinical setting.
  • Afterward, you will be observed for approximately two hours to monitor for any side effects.
  • The Nexus care team will ensure you feel supported and safe throughout the process.

Over time, the frequency of sessions may be reduced based on your progress and how well your body responds. You will also have regular check-ins with your clinician so that your plan can be adjusted as needed. This level of personalized care helps maximize the effectiveness of Spravato and allows you to move forward with confidence.

Contact Us in Pittsburgh Today To Improve Your Symptoms With SPRAVATO

Choosing SPRAVATO in Pittsburgh is an empowering way to take control of your mental health. This advanced treatment helps restore hope for those who are still searching for relief from depression. At The Nexus Group, we are experts in advanced mental health care, and we will be here to guide you every step of the way. Relief could start today—contact us to schedule your initial appointment.

Frequently Asked Questions (FAQ)

Each visit takes about two hours. You will self-administer your Spravato dose in the office with the guidance of our team. Afterward, you’ll stay for a two-hour monitoring period so we can check your blood pressure, oxygen levels, and watch for any potential symptoms or side effects. You’ll need someone to drive you home after each session.

You’ll be in a calm, comfortable setting. You’re welcome to rest, relax, or listen to music. We recommend bringing headphones and choosing instrumental or word-free music to avoid overstimulation. Our care team will check in regularly to ensure your safety and comfort.

Common temporary side effects may include:
  • Sedation
  • Increased blood pressure
  • Feelings of dissociation (e.g., feeling strange or disconnected, or changes in sense of time)
These effects typically occur within the first two hours, which is why you’ll remain under supervision during that time.
First 4 weeks: Twice per week (approx. 2 hours per visit)
Second month: Once per week
Ongoing: Once per week or twice per month, depending on your progress and clinician’s recommendations

No. The FDA prohibits at-home use due to the potential risk of misuse and addiction. Spravato must be administered in a certified medical office under professional supervision.

  • Spravato may not be appropriate for:
  • Individuals under the age of 18
  • Those with uncontrolled high blood pressure
  • A history of substance use disorder involving ketamine or esketamine
  • Brain aneurysms
  • Hemorrhagic strokes
  • Active or uncontrolled psychosis
  • Pregnant or lactating women

Most major insurance companies cover the cost of Spravato treatment. We will work directly with you and your insurance company to help cover the cost of treatment based on your policy.

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